Transcatheter Pulmonary Artery Banding: The UPright™ System

The burden of heart failure

A major global public health problem

60 to 65 millionpeople affected worldwide

~1 millionhospitalizations a year in the United States

40 to 50%five-year mortality in HFrEF

20 to 25%readmitted within 30 days of a heart failure hospitalization

HFrEF accounts for approximately 40 to 50 percent of heart failure cases. Figures are approximate, from published heart failure statistics.

Why a mechanical solution

Hemodynamic burden persists despite optimal therapy

Patients may appear stable at rest. During exercise, filling and pulmonary pressures climb while the rise in cardiac output remains limited.

Guideline-directed medical therapy (GDMT) and device therapies such as CRT and ICD improve survival, but they do not normalize exercise hemodynamics. A major physiological driver of symptoms remains untreated.

The UPright™ System targets the hemodynamic mechanism that drives symptoms

The UPright™ System is implanted in the left and right branches of the pulmonary artery. During exercise, it is designed to reduce distal pulmonary arterial pressure (PAP) and pulmonary capillary wedge pressure (PCWP), while increasing cardiac output (CO) reserve. PCWP is an invasive surrogate of left ventricular (LV) filling pressure and left atrial pressure (LAP).

How it works Mechanism of action

Illustration of the heart with devices in the left and right pulmonary arteries — Devices placed in the left and right pulmonary arteries.

Implant and delivery system

The UPright™ System consists of the implant and a dedicated transcatheter delivery system.

The UPright implant — **Implant**One in each pulmonary artery

The UPright delivery catheter with its handle — **Delivery catheter and control handle**Transvenous, through a femoral vein. The handle provides staged release of the implant.The control handle will be introduced with the UPright™ System.

The UPright delivery system handle — **Delivery catheter and control handle**Transvenous, through a femoral vein. The handle provides staged release of the implant.The control handle will be introduced with the UPright™ System.

At a glance

18Fsystem, delivered through a femoral vein

45 minutesprocedure time

Outside the heartplaced in the pulmonary arteries

Pressure gradientcan be eliminated if needed